A novel thermo-sensitive poly (N-isopropylacrylamide) (PNIPAAm)/ silica nano-composite has been prepared via in situ one-pot method . Effects of factors, such as reaction temperature, reaction time, monomer dosage and initiator dosage on the influence of contact angles were investigated. The optimum surface modification conditions were determined as: reaction temperature was 73℃, reaction time was 6 h, monomers and KH-570 molar ratios is 1, The amount of initiator monomer is 2.5 (wt%)of the total mass amount of monomer and KH-570. The samples were characterized by fourier transform infrared transmission emission microscope (TEM) and dynamic light scatter (DLS). Moreover, the thermo-sensitive property of PNIPAAm was retained in the nano-composite, which had a lower critical solution temperature similar to that of pure PNIPAAm.