Abstract: Preparation of 4-chlorbenzophenone by acylation of benzene with 4-chlorobenzoyl chloride in the presence of FeCl3/ZnCl2 catalyst under pressure was studied. Thus, 157.6 g benzene was mixed with 88.2 g 4-chlorobenzoyl chloride and1.3 g FeCl3/ZnCl2 in a 1L autoclave. The mixture was reacted for 8 h under 0.85×106～1.1×106Pa and 175～185°C to give 93.1g 4-chlorobenzophenone with yield of 86.2% and purity of 99.8%(by HPLC). The effects of pressure, catalyst and ratio of raw materials on the yield were also investigated. The result of our experiments was proved by productive scale up test, in which 175 kg 4-chlorobenzoyl chloride was used as raw material to afford 4-chlorobenzophenone in a molar yield of 82.7%.