The Cu/Ni ultrafine mixed catalyst were prepared by sol-gel technique, the catalysts were applied for liquid phase hydrogenation of furfural to 2-methyltetrahydrofuran. The effects of Cu/Ni molar ratio, concentration of Na2CO3 solution on the properties of the catalyst were investigated, and the effects of reaction pressure, reaction time, reaction temperature on the conversion of furfural and selectivity to 2-methyltetrahydrofuran were studied in detail. The results indicated that catalyst preparation conditions under Cu/Ni molar ratio 5/5, concentration of Na2CO3 solution 1.0mol/l, liquid phase hydrogenation under reaction pressure 8MPa, reaction time 3.5h, reaction temperature 180℃, The conversion of furfural and the selectivity of 2-methyltetrahydrofuran were 100% and 64.52% respectively by GC analysis.