The different loading catalysts of 12-tungstophosphoric acid/SBA-15 were prepared by in-situ method.The structure and properties of the catalysts were characterized by FT-IR spectroscopy、TEM、X-ray diffraction、31P NMR and N2 adsorption-desorption.The results show that the long range order structure on the SBA-15 material is decreased with the improvement of loading. However, the structure of SBA-15 has certain destruction when loading up to 33.3%. The 12-tungstophoaphoric acid highly dispersed in hole of SBA-15 still keeps the Keggin structure, and has certain chemical interaction with surface hydroxy for SBA-15.The catalytic properties of synthetic fruction show that HPW/SBA-15 catalyst have high catalytic activity and selectivity, and show excellent reusabity.