Chitooligosaccharide/salicylic acid microcapsules have been prepared by spray-drying method and the preparation conditions were optimized using the single factor study with oil content and encapsulation efficiency of the microcapsules as criteria. The optimal production conditions are as follows: ρ(chitooligosaccharide)= 2%(w/w), m (chitooligosaccharide):m (salicylic acid) = 1.0:0.5, inlet temperature =170癈, drying air speed= 3.9 m?s-1, rotational speed of pump feed = 8 RPM. Oil content and encapsulation efficiency of the product were 19.1% and 21.5%, respectively. The encapsulation has been confirmed by observing the morphology of microcapsules. The particle size analysis suggested that the average particle size of microcapsules was in the range of 3.154μm ~ 19.751μm. FTIR spectra were used to prove the existence of intermolecular interaction between salicylic acid and chitooligosaccharide. TG-DSC results confirmed the thermal stability of salicylic acid was improved after encapsulating by chitooligosaccharide.