Chloride 1-benzyl-3-(3,5-bis (trifluoromethyl)) phenyl imidazole salt and bromide 1- decyl-3-(3,5-bis (trifluoromethyl)) phenyl imidazole salt were synthesized from 3,5-bis (trifluoromethyl) aniline, formaldehyde, glyoxal, ammonium chloride and benzyl chloride or 1-bromodecane by condensation reaction, nucleophilic substitution reaction and the yields were 59.0% and 77.1%. The compounds of 1-benzyl-3-(3,5-bis (trifluoromethyl)) phenyl imidazole tetrafluoroborate and 1-benzyl-3-(3,5-bis (trifluoromethyl)) phenyl imidazole hexafluorophosphate were designed and synthesized by anion exchange reaction of chloride 1-benzyl-3-(3,5-bis ( trifluoromethyl)) phenyl imidazole salt. All the compounds were characterized by means of 1H NMR and 13C NMR. The effect of solvent on the nucleophilic substitution reaction was studied. The results demonstrated that toluene as solvent, the yield was 59.0%.