Abstract：More than 95% purity of fine chemical intermediates of 1-(4-bromo-phenyl)-propenone was synthesized via Friedel-Crafts and elimination reaction with bromobenzene as the starting material. The target compound was characterized by 1HNMR、IR and GC-MS. The best reaction conditions of Friedel-Crafts and elimination reaction were investigated. The results of condition experiments showed that when n(3-chloropropionyl chloride):n(bromobenzene):n(aluminium chloride)=1.3:1:1.5, and the reaction temperature was 20～25 ℃, the reaction effect of Friedel-Crafts was best. With potassium acetate as the base, when n[1-(4-bromo-phenyl)-3-chloro-propan-1-one]: n[potassium acetate]=1:1.5, and the reaction temperature was 20～25 ℃, the reaction effect of elimination reaction was best.