Improved synthesis of Cetirizine Hydrochloride
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    Abstract:

    This novel is aimed at optimizing and improving the synthesis route of Cetirizine Hydrochloride. The new synthesis route use chlorobenzene and benzoyl chloride as starting materials, through Friedel-crafts reaction, carbonyl reductive reaction, chlorination, nucleophilic substitution, obtained the product. Compared with the original synthesis route, this synthesis route shortened one reaction step, reduced the cost of raw materials, The total yield of Cetirizine Hydrochloride was increased from 20.9% to 24.87%. The structure of product was characterized by IR, 1H NMR and MS.

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History
  • Received:October 02,2013
  • Revised:November 15,2013
  • Adopted:November 18,2013
  • Online: January 03,2014
  • Published:
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