In this article, β-cyclodextrin (β-CD) intercalated ferrum-containing hydrotalcite was fleetly prepared by the technology of the microwave-crystallization and low saturated state of coprecipitation. The purposed sample of β-CD-Fe-LDHs and calcined-β-CD-Fe-LDHs were characterized by XRD, IR and SEM. The results show that the synthesized β-CD-Fe-LDHs with the flexible slice have the structure of LDHs. The calcined product is uniform particle state. Calcined-β-CD-Fe-LDHs was then applied to the removal of parafuchsin. The effects of photocatalyst types, the reaction temperature, parafuchsin mass concentration and cycle life on the parafuchsin removal were investigated. It is shown the percentage of removal for parafuchsin solution of 50 mg/L can reach 95.70% under the optimum conditions, and the removal rate can reach 79.99% even after 5 cycles. The kinetics cuvres of removal show that the removal is first-order kinetics model before 40 minutes under different photocatalyst mass concentrations and parafuchsin mass concentrations. The results suggest that calcined-β-CD-Fe-LDHs can be used as a novel and efficient photocatalyst for the removal of parafuchsin.