Dimethyl 1,4-Cyclohexanedicarboxylate (DMCD) was synthesized by hydrogenation of Dimethyl Terephthalat (DMT) under mild conditions on Nasnoscale RuPd/C Catalysts .Effects of solvent, reaction temperature, pressure and amount of catalyst have been investigated. Under optimal reaction conditions:140℃, 4.0 MPa pressure,isopropanol 2000ml,DMT dosage 1300g, catalyst dosage 65g, conversion of DMT and selectivity to DMCD mount to 99.8% and 96.3% in 5000ml high pressure reactor. After RuPd/C Catalyst was reused for 22 times in the same conditions, the conversion of DMT and selectivity to DMCD still remain at 99.0% and 95.1%, respectively.