Using 2,2-bis(4-hydroxyphenyl)hexafluoropropane as raw materials, 2,2-bis(3-amino-4-hydroxyphenyl)hexafluoropropane was synthesized by nitrification reaction and reduction reaction. The factory pilot-scale study was carried out to determine the technological date after the laboratory experiment succeed. The results indicated that as for the nitrification reaction, n (ethanol)÷n (2,2-bis(4-hydroxyphenyl)hexafluoropropane) = 4, n (the dilute nitric acid)÷n (2,2-bis(4-hydroxyphenyl)hexafluoropropane) = 2.15, 60 ℃ and the reaction time (6 h), which can get the highest 2,2-bis(3-nitro-4-hydroxyphenyl)hexafluoropropane yield (96%). As for the reduction reaction, using FeCl3/ activated carbon as catalyst and ethanol was the solvent, n (hydrazine hydrate)÷n (2,2-bis(3-nitro-4-hydroxyphenyl)hexafluoropropane) = 0.2, m (FeCl3/ activated carbon)÷m (2,2-bis(3-nitro-4-hydroxyphenyl)hexafluoropropane) = 0.05, 85 ℃ and the reaction time (10 h), which can reach the highest 2,2-bis(3-amino-4-hydroxyphenyl)hexafluoropropane yield (92%). The above process conditions have been studied in the factory and determined the technological date and the technological conditions.