Novel six compounds of 3,3,6,6-tetramethyl-9- quinolyl-2,4,5,7,9,10- hexahydroacridine-1,8(2H,5H)-dione were synthesized through the multi-component reaction of 2-chloroquinoline-3-carbaldehyde, dimedone and ammonium acetate in 83%～93% yield under mild condition, and was subsequently cultured into a single crystal. The compound was characterized by means of elemental analysis, IR , 1H NMR, MS and the crystal structure was determined by X-ray single crystal diffraction. The results show that the crystal 3a belongs to the monoclinic system with space group Pccn, with a=2.2291（4）nm, b=1.1923（2）nm, c=1.7274（3）nm, α=β=γ=90°, Dc =1.199g/cm3.