Artificial wastewater which contained sulfadiazine (SD) was electrochemically degraded by intermediate products (•OH and active chlorine) with metallic oxide coatings (DSA) as anode, and titanium plate as cathode in an undivided electric tank. The results indicated that: 1) The removal rate of SD was 100 % after 10 minutes treatment, and the TOC concentration significantly decreased after 4 hours; 2) After 4 h treatment, the removal rates of TOC at pH 3, 4, 8, 8.5, 10 and 12 were 29 %, 46 %, 55 %, 61 %, 52 % and 47 %, respectively, the peak of removal rate appeared at 8.5; 3) The removal rate of TOC could be enhanced through increasing the current density and the NaCl concentration, decreasing the initial SD mass concentration. The optimal treatment process was determined as follows: the pH value of 8.5; the NaCl concentration of 0.025 mol•L−1; the current density of 20 mA•cm−2; the initial SD mass concentration of 100 mg/L. The TOC removal rate could be 66% after 4 h treatment under this reaction conditions according to this research.