The synthesis of 1,3-propylene glycol monoallyl ether was investigated with 1,3-propylene glycol, solid potassium hydroxide and allyl chloride as raw materials, 1,3-propylene glycol as the reaction medium and tetrabutylammonium bromide as phase transfer catalyst. The effects of materials mole ratio, alkali dosage, the mount of catalyst, reaction temperature and time on yield of product were studied. The reaction conditions were optimized by using response surface methodology with three factors and five levels. The optimum conditions were as follows: m(tetrabutylammonium bromide):m(allyl chloride)=5%, n(1,3- propylene glycol):n(potassium hydroxide):n(allyl chloride) =6.3:1.2:1, at 72℃ for 3h. The yield could reach 82.48%. The recovery and reuse of 1,3-propylene glycol could reduce the economic costs. This process has the advantages of low toxicity, low content of by-products, short reaction time and high yield.