Ethylene glycol monoethyl ether acetate was synthesized from ethylene glycol monoethyl ether and acetic acid，high activity of titanium sulfate selected as catalyst.Through single factor experiment,got the proper conditiongs for the synthesis: Based on 0. 2 mol ethylene glycol monoethylether , titanium sulfate/ Ethylene glycol monoethyl ether mass ratio of 0.055:1, acetic acid / ethylene glycol monoethyl ether molar ratio of 1. 5:1, mount of cyclohexane of 15ml, reaction temperature of 130 ℃, and reaction time of 3 h.Under this condition, give the highest yield of ethylene glycol monoethyl ether acetate is above 99%,selecticiy of 100%, Its structure was confirmed by IR, 1HNMR,catalyst reused five times still have high activity , titanium sulfate were characterized by XRD and TPD.