The pivotal intermediate (E)-methyl 2-(2-(bromomethyl)phenyl)-2-(methoxyimino)acetate of Trifoxystrobin was synthesized from 2-methylacetophenone via a serial of reactions included alkaline oxidation with potassium permanganate in the presence of the phase-transfer catalyst, esterification with methanol, oximation with methoxyamine hydrochloride, bromination with N-bromosuccinimide (NBS). The structure was characterized by melting point and 1H-NMR. Under the optimized reaction conditions, the total yield was 52%.