The core-shell latex was synthesized with P(MMA-MAA-BA) as hydrophilic core and P(St-AN-DVB) as hydrophobic hard shell by core-shell emulsion polymerization process, and the covering latex with hollow structure was acquired by post-treatment with alkali. Elements such as MAA acount,core/shell ratio(mass ratio of core monomer and shell monomer, the same below) were traversed which effected hollowness and opacity ability of hollow latex. Structure and morphology of hollow latex particles were characterized by TEM and SEM. The results shown that, when MAA account was 30%(mass fraction) of core monomer and core/shell ratio was 1:6, the latex particles had around 50% hollowness and best opacity ability, and water-based ink therefrom could obtain the best overall performance.