Abstract: M-MCM-41 mesoporous molecular sieve with different metal doping(M=Ce、Y、Nd) was synthesized by hydrothermal method.The surface acidity, mesoporous structure, and chemical state of metal were characterized by X-ray diffraction(XRD), NH3 temperature programmed desorption (NH3-TPD), transmission electron microscopy(TEM), X-ray photoelectron spectroscopy(XPS) and N2 adsorption-desorption. The results indicated that M-MCM-41 mesoporous molecular sieve exhibited the typical hexagonal mesoporous structure, the Specific surface area and pore volume decrease with average pore diameter increasing, The metal element introduced to the molecular sieve was M3 valence state. The M-MCM-41 produced acid with metal doping and corresponding medium strong acid.