Fluorinated quaternary ammonium salts are surfactants, which exhibit some unusual physic-chemical properties, such as high surface activity, high thermally chemical stability, hydrophobic and oleophobic property. In this paper, the effect of the different reaction time, different kinds of oil phase, different mass fractiom and different inorganic salt added ratio on the oil-water interfacial tension was mainly examined. The contact angle formed by different concentration of fluorinated quaternary ammonium salts was also examined to investigate the performance of the wetting spread-ability on the different solid surface such as paraffin and iron. The results showed that the interfacial tension usually achieved basic balance after 10 minutes, and better effect and lower interfacial tension were got when use bohai 61# oil.With the increase of surfactant mass fraction，the interfacial tension was reduced to a minimum, which gradually lapsed into a smooth level. The addition of the inorganic salt made the interfacial tension of the solution first decrease and then increase，and ultra-low interfacial tension appeared in the scope of Sodium chloride concentration in 50-80 g/L, minimum of 0.0531 mN/m. Meanwhile, excellent wetting spread-ability performance was got on the typical surface of the wax which had the low energy and strong hydrophobic. This experiment provided the experimental data for the application in water-soluble occasion.