Synthesis of ( )-ferruginol from ( )-dehydroabietylamine
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TQ031.2

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    Abstract:

    Two new synthetic routes to bioactive diterpene compound ( )-ferruginol starting from ( )-dehydroabietylamine were reported. Route 1: The reductive deamination of ( )-dehydroabietylamine with hydroxylamine-o-sulfonic acid and sodium hydroxide yielded dehydroabietane, followed by Friedel-Crafts acylation, Baeyer-Villiger oxidation and hydrolysis, gave ( )-ferruginol in 29.5% overall yield. Route 2: The reductive deamination of ( )-dehydroabietylamine, then reacted with phthaloyl peroxide to give ( )-ferruginol, overall yield 31.9%.

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History
  • Received:September 14,2014
  • Revised:December 14,2014
  • Adopted:December 15,2014
  • Online: February 09,2015
  • Published:
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