Abstract: A 2-(2-Butoxyethoxy) ethanol acrylate (MBDEGAA) was prepared by esterification of 2-(2-Butoxyethoxy) ethanol (MBDEG) and acrylic acid (AA). The effects of n(AA)∶n(MBDEG), esterification temperature, esterification time, dosages of catalyst and polymerization inhibitor on the esterification ratio were studied. The MBDEGAA structure was identified by means of FT-IR and 1H-NMR. The results show that the highest esterification ratio between MBDEG and AA is 91.20% in the mole ratio of AA to MBDEG as 3.0∶1, esterification temperature as 130 ℃, esterification time as 4.5 h, w(PTSA) as 3.0%, and w(hydroquinone) as 2.0%.