The catalytic performances of 3-Hydroxy-2,2-dimethylpropanal hydrogenation to neopentyl glycol over Cu/SiO2 catalysts were tested in a fixed-bed plug flow reactor. A new type of Cu/SiO2 catalysts modified by four different promoters (Zn, Ni, Mn, Co) were prepared by homogeneous precipitation method. The results showed that the addition of Co promoter on Cu/SiO2 catalysts could promote dispersion of the active component efficiently and stabilize the active center of the catalysts. Evaluation test on activity of the catalysts showed that HPA conversion greater than 99.6% and selectivity to neopentyl glycol about 100% could be obtained under 0.10~0.62 Mpa pressure, temperature of 90℃, mass fraction of HPA at 11.24%, liquid hourly space velocity of 1.4 h-1 and H2/HPA molar ratio of 4 to 1. The unmodified catalyst and the newly prepared ones were characterized by XRD, BET and TG analysis. XRD characterization showed that Co promoter was favorable for the dispersion of CuO, and enhanced the interaction between active component and carrier. Therefore the catalytic activity of the modified catalysts was obviously higher than the original.