Using inexpensive and readily available m-hydroxybenzaldehyde, primary amine and dimethyl carbonate, ortho-anisicaldehyde was synthesized by simple condensation, nucleophilic substitution and hydrolysis reactions under moderate condition. Through screen experiments, excellent synthetic condition which is ortho-hydroxy-benzylidene-butylamine/DMSO/KOH/85oC/24h was established. Comparing to reported methods in 60%-70% yields , the good yield was achieved up to 81% and the method is environmentally friendly. The product was characterized through 1H NMR, 13C NMR spectra and elemental analysis.