Di(2-propyheptyl)-1,2-Cyclohexane Dicarboxylate (DPHCH) was synthesized via esterification between hexahydrophthalic anhydride (HHPA) with 2-propylheptanol by using tetrabutyl titanate as a catalyst. The effects of reaction parameters on esterification were studied by investigating the temperature, reaction time, molar ratio of 2-propylheptanol-to-HHPA, and catalyst content. The results of experiments confirmed the best reaction conditions of esterification as follows: molar ratio of 2-propyl heptanol to HHPA 2.8:1, the reaction temperature was 200℃ and the reaction time was 3 h, amount of catalyst 1.5 %( based on the mass of acid). Furthermore, the esterification yield under present condition was 99.49 % and a colorless transparent oily liquid was obtained. Functional group analysis was conducted by using FTIR and 1H-NMR spectroscopy. weight loss on heating and TG were measured PVC compounds after addition of the synthesized plasticizer DPHCH presented similar plasticizing performance with DEHCH, DOP and DINCH, as demonstrated by comparisons of the results of mechanical properties, weight loss on heating and TG tests obtained for plasticized PVC compounds, indicating its great value in industrial development.