Ketoprofen is a good 2-aryl propanoic acid non-steroidal anti-inflammatory drug (NSAID). The new advances on its synthetic methods and applications of Ketoprofen in recent years have been reviewed in this paper. Based on systematically summarizing the research, improvement, and development of Ketoprofen production process, the typical process routes for synthesis of Ketoprofen with certain industrial potentials, including 2 (or 4)-aminobenzophenone method, 3-methyl-2-indolinone method, 2-(3-benzoylphenyl)propanenitrile method, 3-cyanomethylbenzoic acid method, asymmetric synthesis and enzymatic resolution of S-(+)-Ketoprofen, were analyzed and evaluated. Among these process routes, 2 (or 4)-aminobenzophenone method, 3-methyl-2-indolinone method, 2-(3-benzoylphenyl)propanenitrile method, and 3-cyanomethylbenzoic acid method may be suitable for large-scale production of Ketoprofen. The main directions to processes improvement were also indicated.