A new type of organic silicon long chain organic quaternary ammonium salt fabric softener (VPEQ18) was synthesized by solution polymerization using hydroxypropyl acrylate (HPAA) and allyl polyether epoxy (APE500) and 18 tertiary amine as raw materials, andazodiisobutyronitrile (AIBN) as initiator. Using infrared spectrum to characterization, and analysis shows that VPEQ18 with expected design chemical structure. Using softness, crease elasticity tester, and automatic color difference meter to research the application performance of VPEQ18, and eventually determine the cotton size is 6cm?0cm, VPEQ18 emulsion dosage (30%) for 3 g, curing temperature is 180℃, the curing time of 90 s process conditions, fabric can reach the ideal soft, smooth, antibacterial effect.