The 3-methylamino-1,2-propandiol was synthesized by solid-base carrying triethylamine as catalyst, the 3-chloro-1,2-propanediol and methylamine as the raw materials. The influence factors on this reaction were investigated by orthogonal test and single factor analysis. It was indicated that the best process conditions for this reaction were as follows: the mole ratio of 3-chloro-1,2-propanediol to methylamine (converted into 100%) was 1:8, reaction temperature was 60 ℃, reaction pressure was 0.20 MPa, the reaction time was 3.5 h. Under the optimum reaction conditions, The synthesis yield of 3-methylamino-1,2-propandiol was 91.9%. The product was characterized by elemental analysis, gas chromatography and infrared spectrum method, and the product purity was 99.5% at least.