Abstract: Maleic anhydride(MAH) and β-cyclodextrin(β-CD) were chosen to synthetize vinyl β-cyclodextriny monomer(MAH-β-CD) through alcoholysis reaction, and the quaternary Copolymer was synthesized by the free radical polymerization in aqueous solution, using MAH-β-CD, acrylamide(AM), 2-methyl-2-Acrylic amide propyl sulfonic acid(AMPS) and dimethyl-diallyl-ammonium chloride(DMDAAC) as monomers. The optimum conditions achieved by orthogonal experiment and single factor experiments were that the m(MAH-β-CD):m(AM):m(AMPS): m(DMDAA) was 1:69:20:10, the reaction temperature was 45℃, the monomer concentration was 20%, the polymerization reaction continues 6 h, pH value was 7, and the dosage of initiator was 0.4%(the total mass of monomer).The structures of copolymer were characterized by IR and UV-Vis absorption spectra, indicating that the synthetic product was the target product. The evaluating results showed that the acid dissolving time of 0.8% PAADM is 100 min; Comparison PAADM and PDMC showed that the thermal stability and the slow rate of PAADM were good, and the consistency of the consistency was good.