A series of supported Zn(OAc)2 catalysts were prepared by incipient impregnation and used for synthesis of dimethylhexane-1,6-dicarbamate(HDC) by methoxycarbonylation of 1,6-hexanediamine (HDA) with dimethyl carbonate (DMC). The catalysts were characterized by XRD, BET, NH3-TPD, TG-DTG, FTIR, XPS and the results confirmed that the SiO2 supported Zn(OAc)2 catalyst showed the best activity owing to the formation of Si-O-Zn and the surface acidity which facilitated the activation of DMC and HDA. Under the optimum reaction conditions of 0.02 mmol Zn(OAc)2/mmol HDA, DMC to HDA molar ratio=2, 80 °C and 6 h, the conversion of HDA was 96.0%, the yield of HDC was 68.5%. The used catalyst can be recycled by simply separation and wash, and no obvious deactivation was found even after 5 cycles.