With leucine and phenylalanine as the raw material, we synthesized two C2 symmetrical cyclic decapeptide compounds Q10-1 and Q10-2 in assistance of protection and deprotection of amino acids, N-methyl and coupling, and TBTU / HATU / DEPBT working as cyclization reagents. The cyclization yield reached 31.6% and 39%. The products were isolated and purified by HPLC, which the purity of product was up to 98%. The compound structures were characterized by means of 1HNMR, 13CNMR and ESI-MS．