Atipamzole Hydrochloride was synthesized from 2 - (2 - bromine acetyl) - 2 - ethylindanone through three-step reations includingthe imidazole ring formation, carbonyl reduction and hydrochloric acid .The technological conditions of imidazole ring formation were improved, and the effect of reaction temperature on the yield was investigated, Determined the optimum reaction conditions .The yield of the reaction was increased to 72%. In the process of reduction of the carbonyl group, the method of Huang Minglong reduction was used to replace the original palladium carbon reduction method, and the reaction conditions were optimized by orthogonal experiment. The optimum technological conditions were determined