The deoximation of oximes into their corresponding carbonyl compounds is one of the most important processes in organic synthesis. There has been increasing interest in the development of methods for deoximation. Herein, twelve aldehydes and ketones were synthesized in 68%~92% yields by deoximations of oximes catalyzed with iodine in green solvent water under microwave-assisted condition. The structures of all products were confirmed by the corresponding nuclear magnetic resonance spectrum (1H NMR) and mass spectrum (MS). The effects of solvent, the amount of iodine, microwave power and reaction temperature on the reaction were considered. The optimized reaction conditions: oximes, iodine (50 mol%), and water (1 mol/L), microwave power 300 W, reaction temperature 85 ℃, reaction time 35 min. A possible mechanism was proposed on the results of the experiments.