The traditional Schotten-Baumann reaction uses non eco-friendly fatty acyl chloride and VOC and produces by-product of sodium chloride. A novel synthesis method based on the improved Schotten-Baumann reaction is developed to synthesize sodium N-lauroylglycinate (SLG) from methyl laurate (ML) and sodium glycinate (SG) catalyzed by sodium methoxide (SM) in glycerol, and the final product is confirmed by FT-IR and 1H-NMR as the target molecule of SLG. Some affecting factors on the condensation reaction are investigated such as reaction solvent type, catalyst type, molar ratio of ML to SG, the catalyst dosage of SM, reaction time and temperature, and it is showed that the yield of SLG reached 78.7% under the molar ratios of ML/SG/SM being 1.0 : 2.5 : 0.02 and catalyzed by SM for 3.5 h at 135 oC in glycerol. Compared with the traditional Schotten-Baumann reaction, the improved method is eco-friendly, free from the bothersome by-product of sodium chloride and getting rid of VOC.