the paper reports an efficient method to prepare octacosanol. It started from the economical chemical erucic acid. The route went through acylation, Dieckmann ring-opening, hydrogenation, Wolff-Kishner reduction and LiAlH4 reduction to give octacosanol with 99% purity. This synthetic process contains 6 linear steps with 65.4% overall yield. Furthermore, this method was utilized for 50 kg scale manufacture successfully. The main advantage of the method includes economical and easy availability of starting materials, relatively safe and simple operation, repeatable overall yield and simple purification process for intermediates and final products.