The single epoxy-terminated polydimethylsiloxane (SEPDMS) was prepared with hydrogen-terminated polydimethylsiloxane (HTPDMS) and allyl glycidyl ether (AGE) by hydrosilylation reaction. Subsequently the epoxy functional polysiloxane was grafted to the generation 1 dendritic polyamide-amine (G1 PAMAM). FT-IR, 1H-NMR and nano particle size analyzer were utilized to characterize the structure of the product and the particle size of the emulsion. Finally, the dendritic-linear polymer (G1 PAMAM-Si) was applied to the fatliquoring progress. The structure and performance of fatliquored leather were investigated by SEM and other analysis methods. It was shown that the fatliquored leather with G1 PAMAM-Si exhibits the increasement of collagen fiber distance and improvement of softness and mechanical properties.