ZnO particles of which size was around 180 nm were synthesized by direct precipitation. Indometacin was adsorbed to those particles. The optimal adsorption rate reached up to 74.00±1.11% when the mass ratio was 1:1. The drug release behavior was controlled by the UV radiation, since indometacin largely released under UV radiation while hardly released without UV radiation. The cellular viability of HaCaT was above 78.64±1.24% in the experimental concentration range, showing the good biocompatibility of indometacin loaded ZnO particles.