CuxZn1-xCr0.5Al1.5O4 spinels were prepared by chemical co-precipitation method using Cu(NO3)2, Zn(NO3)2,Cr(NO3)3,Al(NO3)3 and NaOH as raw materials. The structure, physical and chemical properties of spinels were characterized by XRD, ICP, SEM and BET. CuxZn1-xCr0.5Al1.5O4 spinels with different compositions were used as catalysts in the fixed bed reactors for the catalytic synthesis of NMA. The influence of such factors as spinel compositions, reaction temperature, space velocity (WHSV) and molar ratio of reaction raw materials on the catalytic reaction was investigated. The experimental results indicated that reaction temperature of 265℃, WHSV of 0.15h-1 and 3:1 molar ratio of methanol to PA was optimal reaction conditions, and Cu0.5Zn0.5Cr0.5Al1.5O4 had the best catalytic performance. The conversion per pass of PA and the selectivity of NMA were 90.95% and 94.93% respectively.