A pharmaceutical intermediate 6-phenyl-[1,2,4]-triazole[4,3-a]pyridine-3-Amine was synthetized from 5-bromo-2-fluoropyridine by substitution, ring-formation and coupling reactions. The product was characterized by 1H-NMR, 13C-NMR and HRMS. The reaction process was optimized by tuning the reaction time, reaction temperature, reactant ratio, solvent ratio and catalyst dosage to study the effect of these factors on the reaction yield. The results showed that the optimum conditions for the synthesis of 6-bromo-[1,2,4]-triazole[4,3-a]pyridine-3-Amine were as follows: temperature was 40℃ , time was 15 min. The optimum conditions for the synthesis of 6-phenyl-[1,2,4]-triazole[4,3-a]pyridine-3-Amine were as follows: the solvent was V(water): V(dioxane)=1.0:2.0, the amount of the reactant was n(6-bromo- [1,2,4] triazolo [4,3-a] pyridin-3-amine): n(phenylboronic acid) =1.0:1.2, the amount of the catalyst was n(6-bromo- [1,2,4] triazolo [4,3-a] pyridin-3-amine): n(Pd (pph3) 2Cl2）=1.0：0.1, temperature was 80 ℃. The final yield of the three steps of reactions was 60%