Degradable macroporous silica nanoparticle (DMSNs@CS/HA) was prepared from traditionally prepared mesoporous silica using Ca2+ as pore enlarged reagents, and using good biocompatible chitosan (CS) and hyaluronic acid (HA) through layer-by-layer self-assembly technique. The obtained multifunctional nanocarrier was used to load hydrophobic drugs (zinc phthalocyanine) for photodynamics treatment of tumor. Herein, the phase, morphology, pore size distribution, infrared spectroscopy, photodynamics antitumor effect and fluorescence imaging experiment of the as-prepared DMSN@CS/HA were investigated. The survival rate of Hela cells incubated with DMSNs@CS/HA at the concentration of 50 mg/L, reaches up to 93.2%. After loading ZnPc and subjected to the near infrared ray (NIR) irradiation for 10 min, the survival rate sharply decreases to 36.2%. The MTT assay and fluorescence imaging suggest that DMSNs@CS/HA nanocarrier has good biocompatibility, can effectively load ZnPc. And DMSNs@CS/HA@ZnPc shows the excellent photodynamics therapeutic effect under NIR radiation.