Abstract: (R,E)-3-(5-((ethoxycarbonyl)amino)cyclohex-1-en-1-yl)acrylicacid(Ⅰ), the key intermediate of vorapaxar was prepared from (E)-3-(5-nitrocyclohex-1-en-1-yl) acrylicacid(Ⅱ) via esterification, reduction, chiral resolution, condensation and hydrolysis. The reaction conditions were optimized for the synthesis of I. The results showed that ethyl(R,E)-3-(5-amino-cyclohex-1-en-1-yl)acrylate was obtained with a yield of 35.6%, using D-malic acid as separation agent and V(Methanol):V(acetone)=1:1 as solvent. The total yield of this target compound was improved to 27.4%. The structure of target compound was identified by 1HNMR and ESI-MS. The improved process is facile with relatively convenient operation procedures and suitable for industrial production.