SO42-/TiO2-SnO2 as solid acid catalyst was used for the synthesis of 1,4-butanediol acrylate with 1,4- butanediol and acrylic acid as experimental material. The effects of the mole ratio of acid to alcohol, the amount of catalyst, reaction temperature and reaction time on the conversion of 1,4- butanediol and yield of 1,4-butanediol acrylate were studied. The optimized process conditions were obtained by using response surface methodology on the based of single-factor tests. The optimized process conditions were as follow : the mole ratio of acid to alcohol of 2.62:1, the amount of catalyst of 8.88% of the total mass of 1,4- butanediol and acrylic acid, reaction temperature of 136.24℃ and reaction time of 4.68h. Considering the actual situation, the reaction temperature was trimmed about 136℃. Meanwhile, 5 groups of repeated verification experiments were carried and the average yield of 1,4-butanediol acrylate was 88.12%. By the NMR analysis confirmed that the products were 1,4-butanediol acrylate and the physicochemical indexes accord with relevant standards, especially the purity in 95%~98% and the acid value was 0.133 mgKOH/g. This was obviously better than the standards.