Co/TiO2 catalysts with different Co loading amount (w(Co)=10%, 15%, 20% and 25%) were prepared by using a deposition- precipitation method, and applied to the CO2 methanation process, and were characterized by the XRD, TEM, N2 adsorption-desorption, H2-temperature program reduce (H2-TPR), and CO2-temperature program desorption(CO2-TPD). The results showed the crystallite size of the Co3O4, the BET surface area, and the reducing properties were affected by the increase of the cobalt loading amount, and the metal-support interaction was observed between the Co species and the TiO2. The Co/TiO2 catalyst with the Co loading amount of w(Co)=20% exhibited a smaller Co particle size of 8 nm and a good Co dispersion of 10.1%, and the BET surface area and the pore size were 40.9 m2/g and 6.96 nm, respectively. which would favor the CO2 methanation. From the CO2-TPD results, a maximum medium basicity of 28 μmol/g was observed on the Co/TiO2 catalyst with the Co loading amount of w(Co)=20%, which indicated more CO2 molecule were activated on the catalyst surface. The activity test indicated the Co/TiO2 catalyst with the Co loading amount of w(Co)=20% exhibited the highest activities when reacted at 400 ℃ and 0.5 MPa with a gaseous hourly space velocity of 3600 mL/(gcat·h), and the CO2 conversion and CH4 selectivity was 69.9% and 98.3%, respectively, and the Co/TiO2 catalyst kept stable in 20 h.