To optimize the formulation of S( )-IBU/acid-MMT dry suspension by the central composites design-response surface methodology. Using surface area and pore volume as indexes, the influence of hydrochloric acid concentration; reaction time and temperture was investigated by central composite design-response surface method. The results were fitted by second-order polynomial equation, and the optimal preparation technology was predicted according to formulation. The quality of S( )-IBU/acid-MMT composites were characterizedby powder XRD and SEM. Central composite design finalized prescription is 3.3 mol/L, 5.5 h, 55 ℃, its BET surface area and pore volume is 318 m2/g, 0.51 cm3/g, respectively.The acid-MMT loading capacity 460.8 mg/g. Using the central composite design-response surface method to optimize the preparation of S( )-IBU/acid-MMT dry suspension has a good prediction S( )-IBU/acid-MMT dry suspension showsmore capacity by central composites design.