Sugaring-out extraction was adopted to separate polyphenols from Lycium ruthenicum Murr.,which was incubated in the simulated systems at different times levels (0.5-3h )and concentrations (0.2-1.0 mg/m L), which was to observe its inhibitory effect on AGEs. different organic solvent /sugar types system were selected for the further study. The optimization sugaring-out extraction system of 25% (w/w) t-butanol and 19% (w/w) glucose were selected, 2% (w/w)of polyphenols crude extract, 94.15% polyphenols, 94.08% flavones and 94.3% anthocyanins were recovered in the upper phase. Compared with salting-out extraction, the present method exhibited higher extraction effect. The maximum relative inhibitory rate of the solution containing polyphenols with the concentration of 1.0mg/mL on AGEs formation was up to 71.93%?1.32% after heated for 2h at 80℃. Polyphenols could be used as functional food ingredients to inhibit AGE formation.