A series of copper-cobalt composite oxides were synthesized by co-precipitation with different precipitants and the proportion of Cu/Co. The obtained catalysts were further characterized by XRD, SEM, H2-TPR and O2-TPD. The characterization results indicates that the copper-cobalt catalyst prepared by different precipitants shows significant differences in physical and chemical properties. Meanwhile, catalysts using ammonia as precipitant exhibited stronger redox properties and had more chemisorption oxygen. The catalytic activity of the catalysts for oxidative degradation of n-heptane was investigated in a continuous fixed bed reactor with GHSV of 15000h-1, oxygen concentration of 10%. The results indicated that Cu1Co4 catalyst (n(Cu):n(Co)=1:4) performed the best activity in the case of reaction temperature of 185.61℃ and the conversion of n-heptane was 90%. Moreover, the stability test showed that Cu1Co4 was durable. The characterization results of XRD and TG implied that no structural change and no carbon deposition.