In order to improve the electrochemical performances, the precursor of LiNi0.5Mn1.5O4 is synthesized by spray drying and electrospinning. The cathode materials are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The electrochemical performances of the battery are measured by galvanostatic charge-discharge, cyclic voltammetry (CV) and the electrochemical impedance spectroscopy (EIS). The results show that the as-prepared LiNi0.5Mn1.5O4 by spray drying presents the porous-tubular structure, the particle size is about 80 nm, and the cycling performance need to be improved. While the precursor is calcined at 900 ℃ to obtain the spinel LiNi0.5Mn1.5O4 with uniform particle distribution, of which the particle size is between 1 and 2 m by spray drying. The coulombic efficiency of pure LiNi0.5Mn1.5O4 at 0.1C prepared by spray drying and electrospinning are 48.1% and 50.3%, respectively. While the coulombic efficiency of carbon-coated LiNi0.5Mn1.5O4 prepared by spray drying is 53.4% and the capacity retention is still up to 93.3% even after 200 cycles at 1 C-rate, attributed to that the carbon coating layer decreased electrochemical transfer impedance (Rct) and inhibited the side reaction between material and electrolyte.