By using the F127((EO)106(PO)70(EO)106) as the template agent,methyl silicate(TMOS) as the silicon source and the avermectin as the model drug, the avermectin/mesoporous silica(HOMS) was prepared in the method of one-step synthesis.Copper ion, zinc ion and manganese ion were used during the synthetic process in order to form coordinate bond between avermectin and mesoporous silica,and thus,three kinds of pH-responsive slow-released systems(AVM/Zn-HOMS, AVM/Cu-HOMS and AVM/Mn-HOMS) were build up.The materials’ structures were systematically studied using Fourier transform infrared spectroscopy(FTIR),N2 adsorption-desorption, scanning electron microscopy(SEM) and thermogravimetric analysis(TGA) measurements, and the release behaviour under different pH values was also studied.The results showed that, stratiform structure, multihole structure and bubble structure were observed on the surface appearance of AVM/Zn-HOMS,AVM/Cu-HOMS and AVM/Mn-HOMS, respectively. Compared with AVM/HOMS, the surface areas of AVM/Zn-HOMS, AVM/Cu-HOMS and AVM/Mn-HOMS had an enlargement about 308.581,101.218 and 318.011 m2/g,respectively.The N2 adsorption-desorption isotherms of the systems were H1 hysteresis loops of the type LangmuirⅣ. AVM/Zn-HOMS and AVM/Cu-HOMS showed obvious pH responsiveness, while AVM/Mn-HOMS didn’t exhibited obvious pH responsiveness. The release process could be described by Higuchi kinetic model. The diffusion mechanism dominated the release process.