Abstract：β-Cyclodextrin/epichlorohydrin copolymer(β-CDP) was synthesized in alkaline medium using β-cyclodextrin as monomer and epichlorohydrin as crosslinker. β-CDP was used as adsorbent for the adsorption of diphenolic acid (DPA) from the water solution. The influence of pH and β-CDP to DPA mass ratio for the DPA adsorption was investigated. The results showed that the adsorption efficiency was fairly good when the pH was less than 4.3 and the mass ratio of β-CDP to DPA was 12.5. At the same time, the mechanism of β-CDP adsorption for the DPA was discussed. β-CDP had a rapid adsorption rate for the removal of DPA from water solution, the hydrogen bond and hydrophobic interaction had important effort on the adsorption process. The adsorption kinetics agreed with the pseudo second-order kinetic model. Langmuir and Freundlich isotherm models were well described. The thermodynamic experiment was spontaneous and exothermic in nature. β-CDP had good regeneration performance, the adsorption capacity of β-CDP was 90% after five cycles of adsorption-desorption.