2,8-dibromo-11H-pyrido[2,1-b]quinazolin-11-one was synthesized from 5-bromoisatin, 2,5-dibromopyridine. Then three new quinazolinone derivatives with yields between 68% and 85% were synthesized via suzuki coupling, structures of the compounds were identified by nuclear magnetic resonance spectroscopy and mass spectroscopy．Their optical physical properties were investigated by UV-Vis and fluorescence spectroscopy．Their electrochemical properties were studied by cyclic voltammetry and theoretical calculation methods. The results showed that the introduction of donor groups on the planar structure of parent ring extend the π-conjugation system, reduced the π-π intermolecular stacking of parent ring compound, and the formation of push-pull structure by connecting donor groups to quinazolinone backbone decreased energy gap of entire molecule. These quinazolinone derivatives are a kind of potential third-order nonlinear optical materials．