Pd/Ni bimetal heterogeneous catalyst (Fe3O4@La-MOF-Schiff-Pd/Ni) containging magenic Fe3O4 nanoparticles was prepared by a post-synthesis modification method and characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), energy dispersive spectrum (EDS), inductive coupled plasma optical emission spectroscope (ICP), powder X-ray diffraction (PXRD) and X-ray photoelectron spectroscope (XPS). The results showed that Fe3O4 nanoparticles were successfully embedded in La-MOF. The active sites of Pd and Ni were uniformly dispersed in the La-MOF after the post-synthetic modification. The catalyst exhibited high catalytic activity in the Suzuki coupling reaction. When iodobenzene (1.0 mmol) and phenylboronic acid (1.2 mmol) were used as reactants, K2CO3 was used as base, anhydrous ethanol was used as solvent, the amount of catalyst used was 8 mg, the yield of biphenyl was 95% at a reaction temperature of 80℃and a reaction time of 6 h. The catalyst could be easily recovered by magnetic separation and maintain high catalytic activity (82%) after 5 cycles. The proposed mechanism for the Suzuki coupling reaction revealed that Pd and Ni had a synergistic effect on catalytic activity. Moreover, the as-synthesized bimetallic catalyst demonstrated a common applicability to aryl bromides and iodides containing different substituents.